Microstructural changes in the brain mediate the association of AK4, IGFBP5, HSPB2, and ITPK1 with cognitive decline.
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ABSTRACT:
SUBMITTER: Kim N
PROVIDER: S-EPMC7077920 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
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Microstructural changes in the brain mediate the association of AK4, IGFBP5, HSPB2, and ITPK1 with cognitive decline.
Kim Namhee N Yu Lei L Dawe Robert R Petyuk Vladislav A VA Gaiteri Chris C De Jager Philip L PL Schneider Julie A JA Arfanakis Konstantinos K Bennett David A DA
Neurobiology of aging 20190726
The associations of 4 proteins-AK4, ITPK1, HSPB2, and IGFBP5-with cognitive function in older adults were largely unexplained by known brain pathologies. We examined the extent to which individual protein associations with cognitive decline were attributable to microstructural changes in the brain. This study included 521 participants (mean age 90.3, 65.9-108.3) with the postmortem reciprocal of transverse relaxation time (R<sub>2</sub>) magnetic resonance image. All participants came from one o ...[more]
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2009-01-15 | GSE13799 | GEO