Interplay between Cocaine, Drug Removal, and Methylphenidate Reversal on Phospholipid Alterations in Drosophila Brain Determined by Imaging Mass Spectrometry.

ABSTRACT: Cocaine dependence displays a broad impairment in cognitive performance including attention, learning, and memory. To obtain a better understanding of the action of cocaine in the nervous system, and the relation between phospholipids and memory, we have investigated whether phospholipids recover in the brain following cocaine removal using the fly model, Drosophila melanogaster. In addition, the effects of methylphenidate, a substitute medication for cocaine dependence, on fly brain lipids after cocaine abuse are also determined to see if it can rescue the lipid changes caused by cocaine. Time of flight secondary ion mass spectrometry with a (CO₂)₆₀₀₀⁺ gas cluster ion beam was used to detect intact phospholipids. We show that cocaine has persistent

SUBMITTER: Philipsen MH 

PROVIDER: S-EPMC7077924 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature