Testosterone Increases the Expression and Phosphorylation of AMP Kinase α in Men With Hypogonadism and Type 2 Diabetes.

ABSTRACT: Adenosine 5'-monophosphate-activated protein kinase-α (AMPKα) is a mediator of exercise-induced glucose uptake in skeletal muscle. We evaluated whether AMPKα expression and phosphorylation are reduced in skeletal muscle and adipose tissue of patients with hypogonadotropic hypogonadism (HH), and whether testosterone replacement therapy results in restoration of the expression and phosphorylation of AMPKα. This is a secondary analysis of a previously completed trial that showed an insulin-sensitizing effect of testosterone therapy in men with type 2 diabetes and HH. Clinical research center at university. Thirty-two men with HH and 32 eugonadal men were compared at baseline. Men with HH were treated with intramuscular injections of testosterone or placebo every 2 weeks for 22 weeks. Quadrice

SUBMITTER: Ghanim H 

PROVIDER: S-EPMC7077952 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature