Signalling lymphocyte activation molecule family member 9 is found on select subsets of antigen-presenting cells and promotes resistance to Salmonella infection.

ABSTRACT: Signalling lymphocyte activation molecule family member 9 (SLAMF9) is an orphan receptor of the CD2/SLAM family of leucocyte surface proteins. Examination of SLAMF9 expression and function indicates that SLAMF9 promotes inflammation by specialized subsets of antigen-presenting cells. Within healthy liver and circulating mouse peripheral blood mononuclear cells, SLAMF9 is expressed on CD11b⁺ , Ly6C^- , CD11c^low , F4/80^low , MHC-II⁺ , CX₃ CR1⁺ mononuclear phagocytes as well as plasmacytoid dendritic cells. In addition, SLAMF9 can be found on peritoneal B1 cells and small (F4/80^low ), but not large (F4/80^high ), peritoneal macrophages. Upon systemic challenge with Salmonella enterica Typhimurium,

SUBMITTER: Wilson TJ 

PROVIDER: S-EPMC7078004 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature