Bodyweight threshold for sudden onset of ketosis might exist in ketosis-prone type 2 diabetes patients.

ABSTRACT: Ketosis-prone type 2 diabetes is recognized as atypical diabetes. These patients are often male, characterized by obesity, sudden onset of ketosis and a transient decrease in insulin secretion capacity that can be recovered with temporal insulin therapy. Here, we report a male patient with ketosis-prone type 2 diabetes who was followed up for 8 years. During the follow-up period, his bodyweight fluctuated and he experienced four episodes of critical ketosis recurrence in association with bodyweight gain. He discontinued insulin therapy after each ketosis episode within the first 4 years, but thereafter, he had to continue insulin therapy because of decreased insulin secretion capacity. Interestingly, his peak bodyweight just before the repeated ketosis episode gradually decreased, and the

SUBMITTER: Satomura A 

PROVIDER: S-EPMC7078091 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature