Long-term outcome of islet transplantation on insulin-dependent diabetes mellitus: An observational cohort study.

ABSTRACT:

Aims/introduction

To investigate the long-term efficacy and safety of islet transplantation (ITx) compared with multiple daily injections (MDI) or continuous subcutaneous insulin infusion (CSII).

Materials and methods

Among 619 patients diagnosed as insulin-dependent diabetes mellitus or type 1 diabetes at Kyoto University, Kyoto, Japan, seven patients were selected as the ITx group and 26 age-matched patients with no endogenous insulin secretion were selected as the MDI/CSII group. Hemoglobin A1c, aspartate aminotransferase/alanine aminotransferase (AST/ALT) and creatinine were assessed retrospectively at 1, 2, 5 and 10 years for both groups; serum C-peptide immunoreactivity was assessed for the ITx group. Major clinical events were also assessed.

Results

Hemoglobin

SUBMITTER: Nakamura T 

PROVIDER: S-EPMC7078128 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature