Dietary glycaemic index, glycaemic load and head and neck cancer risk: a pooled analysis in an international consortium.

ABSTRACT: High dietary glycaemic index (GI) and glycaemic load (GL) may increase cancer risk. However, limited information was available on GI and/or GL and head and neck cancer (HNC) risk. We conducted a pooled analysis on 8 case-control studies (4081 HNC cases; 7407 controls) from the International Head and Neck Cancer Epidemiology (INHANCE) consortium. We estimated the odds ratios (ORs) and 95% confidence intervals (CIs) of HNC, and its subsites, from fixed- or mixed-effects logistic models including centre-specific quartiles of GI or GL. GI, but not GL, had a weak positive association with HNC (OR_{Q4 vs. Q1} = 1.16; 95% CI = 1.02-1.31). In subsites, we found a positive association between GI and laryngeal cancer (OR_{Q4 vs. Q1} = 1.60; 95% CI = 1.30-1.96) and an inverse associat

SUBMITTER: Chang CP 

PROVIDER: S-EPMC7078183 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature