Adverse birth outcomes in adolescent and young adult female cancer survivors: a nationwide population-based study.

ABSTRACT:

Background

For female adolescent and young adult (AYA), cancer with treatments may affect their children's health. Our aim was to determine reliable risk estimates of adverse birth outcomes in AYA cancer survivors and the differential effects of treatments.

Methods

The study population of 4547 births in the AYA cancer survivor group and 45,463 in the comparison group were identified from two national databases between 2004 and 2014. Detailed maternal health conditions, such as maternal comorbidities, medication use during pregnancy and lifestyles, were adjusted in the statistical analyses. The outcomes included low birth weight, preterm labour, stillbirth, small or large for gestational age, a 5-min Apgar score <7, congenital malformation and foetal distress.

Results

SUBMITTER: Kao WH 

PROVIDER: S-EPMC7078184 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature