Lipoic acid decreases breast cancer cell proliferation by inhibiting IGF-1R via furin downregulation.

ABSTRACT:

Background

Breast cancer is the second most common cancer in the world. Despite advances in therapies, the mechanisms of resistance remain the underlying cause of morbidity and mortality. Lipoic acid (LA) is an antioxidant and essential cofactor in oxidative metabolism. Its potential therapeutic effects have been well documented, but its mechanisms of action (MOA) are not fully understood.

Methods

The aim of this study is to validate the inhibitory LA effect on the proliferation of various breast cancer cell lines and to investigate the MOA that may be involved in this process. We tested LA effects by ex vivo studies on fresh human mammary tumour samples.

Results

We demonstrate that LA inhibits the proliferation and Akt and ERK signalling pathways of several breast ca

SUBMITTER: Farhat D 

PROVIDER: S-EPMC7078196 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature