The association between colorectal cancer and prior antibiotic prescriptions: case control study.

ABSTRACT:

Background

Antibiotic use over several decades is believed to be associated with colorectal adenomas. There is little evidence, however, for the effect of more recent antibiotic use on frequency of colorectal cancers.

Methods

A case control study used the RCGP's Research and Surveillance Centre cohort of patients drawn from NHS England. In all, 35,214 patients with a new diagnosis of colorectal cancer between 1 January 2008 and 31 December 2018 were identified in the database and were matched with 60,348 controls. Conditional logistic regression was used to examine the association between antibiotic prescriptions and colorectal cancer.

Results

A dose-response association between colorectal cancers and prior antibiotic prescriptions was observed. The risk was related t

SUBMITTER: Armstrong D 

PROVIDER: S-EPMC7078217 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature