Further confirmation of netrin 1 receptor (DCC) as a depression risk gene via integrations of multi-omics data.

ABSTRACT: Genome-wide association studies (GWAS) of major depression and its relevant biological phenotypes have been extensively conducted in large samples, and transcriptome-wide analyses in the tissues of brain regions relevant to pathogenesis of depression, e.g., dorsolateral prefrontal cortex (DLPFC), have also been widely performed recently. Integrating these multi-omics data will enable unveiling of depression risk genes and even underlying pathological mechanisms. Here, we employ summary data-based Mendelian randomization (SMR) and integrative risk gene selector (iRIGS) approaches to integrate multi-omics data from GWAS, DLPFC expression quantitative trait loci (eQTL) analyses and enhancer-promoter physical link studies to prioritize high-confidence risk genes for depression, followed by ind

SUBMITTER: Li HJ 

PROVIDER: S-EPMC7078234 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature