New Therapeutic Candidates for the Treatment of Malassezia pachydermatis -Associated Infections.

ABSTRACT: The opportunistic pathogen Malassezia pachydermatis causes bloodstream infections in preterm infants or individuals with immunodeficiency disorders and has been associated with a broad spectrum of diseases in animals such as seborrheic dermatitis, external otitis and fungemia. The current approaches to treat these infections are failing as a consequence of their adverse effects, changes in susceptibility and antifungal resistance. Thus, the identification of novel therapeutic targets against M. pachydermatis infections are highly relevant. Here, Gene Essentiality Analysis and Flux Variability Analysis was applied to a previously reported M. pachydermatis metabolic network to identify enzymes that, when absent, negatively affect biomass production. Three novel therapeutic targets (i.e., hom

SUBMITTER: Sastoque A 

PROVIDER: S-EPMC7078309 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature