The method simulating spontaneous pain in patients with nociplastic pain using rats with fibromyalgia-like condition.

ABSTRACT: The method shown in this article simulates spontaneous pain in patients with nociplastic pain using rats; the measurement with this method could be related to better translation of analgesic efficacies of therapeutic compounds between rats and humans. Nociplastic pain occurs in various disorders including fibromyalgia. Because the pain in patients occurs without an external stimulus, we assessed spontaneous pain in rats. The grimace scale, a methodology for rating facial expression, has been used for measuring spontaneous pain in animals. However, the responses in animals have been rather short-lived, and the scale has never been applied to animals exhibiting nociplastic pain. Here, we apply the rat grimace scale (RGS) to the reserpine-induced fibromyalgia-like rat, which induces nociplast

SUBMITTER: Tanei S 

PROVIDER: S-EPMC7078388 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature