Feasibility of 4D CT simulation with synchronized intravenous contrast injection in hepatocellular carcinoma.

ABSTRACT:

Background

Delivering Stereotactic Body Radiotherapy (SBRT) for Hepatocellular Carcinoma (HCC) is challenging mainly for two reasons: first, motion of the liver occurs in six degrees of freedom and, second, delineation of the tumor is difficult owing to a similar density of HCC to that of the adjoining healthy liver tissue in a non-contrast CT scan. To overcome both these challenges simultaneously, we performed a feasibility study to synchronize intravenous contrast to obtain an arterial and a delayed phase 4D CT.

Materials and methods

We included seven HCC patients of planned for SBRT. 4D CT simulation was performed with synchronized intravenous contrast based on the formula T_{SCAN DELAY} = T _peak - (L₀/Detector Coverage × Cine D

SUBMITTER: Gupta A 

PROVIDER: S-EPMC7078516 | biostudies-literature | 2020 Mar-Apr

REPOSITORIES: biostudies-literature