Biotin Supplementation Ameliorates Murine Colitis by Preventing NF-κB Activation.

ABSTRACT:

Background & aims

Biotin is a water-soluble vitamin that is indispensable for human health. Biotin deficiency can cause failure-to-thrive, immunodeficiency, alopecia, dermatitis, and conjunctivitis. We previously reported that biotin deficiency also can lead to severe colitis in mice, which is completely reversed with supplementation. Our aim in this study was to determine if high-dose biotin supplementation can provide a therapeutic benefit in a preclinical model for inflammatory bowel disease (IBD) and to identify the molecular mechanism by which this occurs.

Methods

Mice were challenged with dextran sodium sulfate to induce colitis and were treated with 1 mmol/L biotin to induce or maintain remission. Clinical response was monitored by the Disease Activity Index and fecal

SUBMITTER: Skupsky J 

PROVIDER: S-EPMC7078531 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature