Transcriptional Responses of Dictyostelium discoideum Exposed to Different Classes of Bacteria.

ABSTRACT: Dictyostelium discoideum amoebae feed by ingesting bacteria, then killing them in phagosomes. Ingestion and killing of different bacteria have been shown to rely on largely different molecular mechanisms. One would thus expect that D. discoideum adapts its ingestion and killing machinery when encountering different bacteria. In this study, we investigated by RNA sequencing if and how D. discoideum amoebae respond to the presence of different bacteria by modifying their gene expression patterns. Each bacterial species analyzed induced a specific modification of the transcriptome. Bacteria such as Bacillus subtilis, Klebsiella pneumoniae, or Mycobacterium marinum induced a specific and different transcriptional response, while Micrococcus luteus did

SUBMITTER: Lamrabet O 

PROVIDER: S-EPMC7078664 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature