Substance use disorders and risk for treatment resistant depression: a population-based, nested case-control study.

ABSTRACT:

Background and aims

Treatment-resistant depression (TRD), defined as inadequate treatment response after at least two adequate treatment trials, is common among patients initiating antidepressant treatment. Current or previous substance use disorders (SUD) are common among patients with depression and often lead to worse treatment outcomes. However, in clinical studies, SUD have not been found to increase the risk for TRD. The aim of this study was to investigate the association between SUD and TRD.

Design

Nested case-control study.

Setting

Nation-wide governmental health-care registers in Sweden.

Cases and controls

Data on prescribed drugs and diagnoses from specialized health care were used to establish a prospectively followed cohort of antidepressant initia

SUBMITTER: Brenner P 

PROVIDER: S-EPMC7078870 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature