Fertility factors affect the vaginal microbiome in women of reproductive age.

ABSTRACT:

Problem

For women of reproductive age, achieving a successful pregnancy requires both the normal functioning of reproductive endocrine and the health of the reproductive tract environment. We aimed to study how these fertility factors, such as female age, baseline sexual hormone levels, tubal patency, and vaginal pH, affect the composition of vaginal microbiome.

Method of study

The 16S rRNA sequencing was carried on vaginal microbiome samples from 85 women of reproductive age without vaginal infections or reproductive endocrine diseases. The detailed correlations between fertility factors and vaginal microbiome were quantified by Spearman's rank tests. A linear discriminant analysis was carried out to explore the effects of fertility factors on the relative abundances of vag

SUBMITTER: Xu J 

PROVIDER: S-EPMC7078941 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature