Stereoselective Allylic Alkylations of Amino Ketones and Their Application in the Synthesis of Highly Functionalized Piperidines.

ABSTRACT: Chelated ketone enolates are excellent nucleophiles for allylic alkylations. Electron-withdrawing groups on the allyl moiety allow subsequent intramolecular Michael additions giving rise to piperidines with up to five stereogenic centers.

SUBMITTER: Prudel C 

PROVIDER: S-EPMC7079034 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature