Genetic variants of innate immunity receptors are associated with mortality in cirrhotic patients with bacterial infection.

ABSTRACT:

Background & aims

Acute-on-chronic liver failure (ACLF) is characterized by acute decompensation of cirrhosis (AD), organ failure(s) and high risk of short-term mortality with bacterial infection frequently as precipitating event. Innate immune pattern recognition receptors and members of the lectin pathway of complement activation are crucial to the innate immune response to pathogens. The aim of this study was to investigate whether single nucleotide polymorphisms (SNPs) of innate immune components are associated with the occurrence of bacterial infections or mortality in patients with cirrhosis hospitalized for AD or ACLF.

Methods

Twenty-one innate immunity SNPs with known functional implications were genotyped in 826 AD/ACLF patients included in the CANONIC study. Associ

SUBMITTER: Schaapman JJ 

PROVIDER: S-EPMC7079071 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature