Time-to-Event Modeling for Remimazolam for the Indication of Induction and Maintenance of General Anesthesia.

ABSTRACT: Remimazolam is an ultra-short-acting benzodiazepine being investigated for induction and maintenance of general anesthesia and for procedural sedation. This dose-response analysis of 4 phase 2-3 studies evaluated covariates that may impact the pharmacodynamic profile (based on theoretical pharmacokinetic principles) and require dose adjustments in subpopulations, particularly elderly, and if remimazolam has cumulative properties. Covariates affecting the time to loss of consciousness and time to extubation were evaluated using Cox proportional hazards models. Factors affecting steady-state infusion rate required to produce adequate sedation were evaluated using linear regression. Variability in time to loss of consciousness was explained by induction dose, age, body mass index, and time fr

SUBMITTER: Lohmer LL 

PROVIDER: S-EPMC7079111 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature