Individual participant data meta-analysis of intervention studies with time-to-event outcomes: A review of the methodology and an applied example.

ABSTRACT: Many randomized trials evaluate an intervention effect on time-to-event outcomes. Individual participant data (IPD) from such trials can be obtained and combined in a so-called IPD meta-analysis (IPD-MA), to summarize the overall intervention effect. We performed a narrative literature review to provide an overview of methods for conducting an IPD-MA of randomized intervention studies with a time-to-event outcome. We focused on identifying good methodological practice for modeling frailty of trial participants across trials, modeling heterogeneity of intervention effects, choosing appropriate association measures, dealing with (trial differences in) censoring and follow-up times, and addressing time-varying intervention effects and effect modification (interactions).We discuss how to achie

SUBMITTER: de Jong VMT 

PROVIDER: S-EPMC7079159 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature