Nickel-Catalyzed Anionic Cross-Coupling Reaction of Lithium Sulfonimidoyl Alkylidene Carbenoids With Organolithiums.

ABSTRACT: The mechanistic platform for a novel nickel⁰ -catalyzed anionic cross-coupling reaction (ACCR) of lithium sulfonimidoyl alkylidene carbenoids (metalloalkenyl sulfoximines) with organometallic reagents is reported herein, affording substituted alkenylmetals and lithium sulfinamides. The Ni⁰ -catalyzed ACCR of three different types of metalloalkenyl sulfoximines, including acyclic, axially chiral and exocyclic derivatives, with sp² organolithiums and sp² and sp³ Grignard reagents has been studied. The ACCR of metalloalkenyl sulfoximines with PhLi in the presence of the Ni⁰ -catalyst and precatalyst Ni(PPh₃ )₂ Cl₂ afforded alkenyllithiums, under inversion of configuration at the C atom and compl

SUBMITTER: Erdelmeier I 

PROVIDER: S-EPMC7079181 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature