Revealing hidden information in osteoblast's mechanotransduction through analysis of time patterns of critical events.

ABSTRACT:

Background

Mechanotransduction in bone cells plays a pivotal role in osteoblast differentiation and bone remodelling. Mechanotransduction provides the link between modulation of the extracellular matrix by mechanical load and intracellular activity. By controlling the balance between the intracellular and extracellular domains, mechanotransduction determines the optimum functionality of skeletal dynamics. Failure of this relationship was suggested to contribute to bone-related diseases such as osteoporosis.

Results

A hybrid mechanical and agent-based model (Mech-ABM), simulating mechanotransduction in a single osteoblast under external mechanical perturbations, was utilised to simulate and examine modulation of the activation dynamics of molecules within mechanotransduction

SUBMITTER: Ascolani G 

PROVIDER: S-EPMC7079370 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature