Ontology highlight
ABSTRACT:
SUBMITTER: Kumar V
PROVIDER: S-EPMC7079562 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Kumar Vathan V Tan Kian-Pin KP Wang Ying-Ming YM Lin Sheng-Wei SW Liang Po-Huang PH
Bioorganic & medicinal chemistry 20160512 13
Severe acute respiratory syndrome (SARS) led to a life-threatening form of atypical pneumonia in late 2002. Following that, Middle East Respiratory Syndrome (MERS-CoV) has recently emerged, killing about 36% of patients infected globally, mainly in Saudi Arabia and South Korea. Based on a scaffold we reported for inhibiting neuraminidase (NA), we synthesized the analogues and identified compounds with low micromolar inhibitory activity against 3CL(pro) of SARS-CoV and MERS-CoV. Docking studies s ...[more]