Impact of a reminder/extinction procedure on threat-conditioned pupil size and skin conductance responses.

ABSTRACT: A reminder can render consolidated memory labile and susceptible to amnesic agents during a reconsolidation window. For the case of threat memory (also termed fear memory), it has been suggested that extinction training during this reconsolidation window has the same disruptive impact. This procedure could provide a powerful therapeutic principle for treatment of unwanted aversive memories. However, human research yielded contradictory results. Notably, all published positive replications quantified threat memory by conditioned skin conductance responses (SCR). Yet, other studies measuring SCR and/or fear-potentiated startle failed to observe an effect of a reminder/extinction procedure on the return of fear. Here we sought to shed light on this discrepancy by using a different autonomic r

SUBMITTER: Zimmermann J 

PROVIDER: S-EPMC7079572 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature