Cognitive correlates of cerebellar resting-state functional connectivity in Parkinson disease.

ABSTRACT:

Objective

To investigate in a cross-sectional study the contributions of altered cerebellar resting-state functional connectivity (FC) to cognitive impairment in Parkinson disease (PD).

Methods

We conducted morphometric and resting-state FC-MRI analyses contrasting 81 participants with PD and 43 age-matched healthy controls using rigorous quality assurance measures. To investigate the relationship of cerebellar FC to cognitive status, we compared participants with PD without cognitive impairment (Clinical Dementia Rating [CDR] scale score 0, n = 47) to participants with PD with impaired cognition (CDR score ≥0.5, n = 34). Comprehensive measures of cognition across the 5 cognitive domains were assessed for behavioral correlations.

Results

The participants with PD had s

SUBMITTER: Maiti B 

PROVIDER: S-EPMC7079688 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature