Apathy rating scores and β-amyloidopathy in patients with Parkinson disease at risk for cognitive decline.

ABSTRACT:

Objective

To determine whether β-amyloidopathy correlates with apathy rating scores independently of mood changes and other neurodegenerative processes in Parkinson disease (PD).

Methods

In this cross-sectional study, patients with PD (n = 64, 48 male and 16 female, mean age 69.2 ± 6.7 years, Hoehn & Yahr stage 2.7 ± 0.5, Montreal Cognitive Assessment score 25.3 ± 3.0) underwent [¹¹C]Pittsburgh compound B β-amyloid, [¹¹C]dihydrotetrabenazine vesicular monoamine transporter type 2 (VMAT2), and [¹¹C]methyl 4 piperidinyl propionate acetylcholinesterase brain PET imaging and clinical assessments, including the Marin Apathy Evaluation Scale, Clinician Version. Patients were recruited on the basis of having at least 1 risk factor for PD dementia, b

SUBMITTER: Zhou Z 

PROVIDER: S-EPMC7079689 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature