A persistently infecting coronavirus in hibernating Myotis lucifugus, the North American little brown bat.

ABSTRACT: Bats are important reservoir hosts for emerging viruses, including coronaviruses that cause diseases in people. Although there have been several studies on the pathogenesis of coronaviruses in humans and surrogate animals, there is little information on the interactions of these viruses with their natural bat hosts. We detected a coronavirus in the intestines of 53/174 hibernating little brown bats (Myotis lucifugus), as well as in the lungs of some of these individuals. Interestingly, the presence of the virus was not accompanied by overt inflammation. Viral RNA amplified from little brown bats in this study appeared to be from two distinct clades. The sequences in clade 1 were very similar to the archived sequence derived from little brown bats and the sequences from clade 2 were more cl

SUBMITTER: Subudhi S 

PROVIDER: S-EPMC7079692 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature