Censoring-robust estimation in observational survival studies: Assessing the relative effectiveness of vascular access type on patency among end-stage renal disease patients.

ABSTRACT: The proportional hazards model is commonly used in observational studies to estimate and test a predefined measure of association between a variable of interest and the time to some event T. For example, it has been used to investigate the effect of vascular access type in patency among end-stage renal disease patients (Gibson et al., J Vasc Surg 34:694-700, 2001). The measure of association comes in the form of an adjusted hazard ratio as additional covariates are often included in the model to adjust for potential confounding. Despite its flexibility, the model comes with a rather strong assumption that is often not met in practice: a time-invariant effect of the covariates on the hazard function for T. When the proportional hazards assumption is violated, it is well known in the literat

SUBMITTER: Nguyen VQ 

PROVIDER: S-EPMC7079760 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature