Steroid therapy and the risk of osteonecrosis in SARS patients: a dose-response meta-analysis.

ABSTRACT: This meta-analysis synthesized current evidence from 10 trials to evaluate the association between steroid therapy and osteonecrosis incidence in patients with severe acute respiratory syndrome (SARS). Our results suggest that higher cumulative doses and longer treatment durations of steroids are more likely to lead to the development of osteonecrosis in SARS patients.

Introduction

The link between steroid treatment and the risk of osteonecrosis in SARS patients remains unknown. The present meta-analysis aimed to examine the dose-response association between steroid therapy and osteonecrosis incidence in SARS patients. The sex differences in the development of steroid-induced osteonecrosis were also examined.

Methods

We searched PubMed, Web of Science, CNKI, and WANFANG for s

SUBMITTER: Zhao R 

PROVIDER: S-EPMC7079838 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature