Immune responses induced by recombinant Lactobacillus plantarum expressing the spike protein derived from transmissible gastroenteritis virus in piglets.

ABSTRACT: Transmissible gastroenteritis coronavirus (TGEV) is one of the most severe threats to the swine industry. In this study, we constructed a suite of recombinant Lactobacillus plantarum with surface displaying the spike (S) protein coming from TGEV and fused with DC cells targeting peptides (DCpep) to develop an effective, safe, and convenient vaccine against transmissible gastroenteritis. Our research results found that the recombinant Lactobacillus plantarum (NC8-pSIP409-pgsA-S-DCpep) group expressing S fused with DCpep could not only significantly increase the percentages of MHC-II⁺CD80⁺ B cells and CD3⁺CD4⁺ T cells but also the number of IgA⁺ B cells and CD3⁺CD4⁺ T cells of ileum lamina propria, which elevated th

SUBMITTER: Jin YB 

PROVIDER: S-EPMC7080080 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature