Vascular safety of erenumab for migraine prevention.

ABSTRACT:

Objective

To examine the cardiovascular, cerebrovascular, and peripheral vascular safety of erenumab across migraine prevention studies.

Methods

Vascular adverse events (AEs) and blood pressure data were integrated across 4 double-blind, placebo-controlled studies of erenumab and their open-label extensions in patients with chronic or episodic migraine. Subgroup analyses were conducted by acute migraine-specific medication use and number of vascular risk factors at baseline. Standardized search terms were used to identify vascular AEs (cardiovascular, cerebrovascular, or peripheral). An independent committee adjudicated whether targeted events were vascular in origin.

Results

In placebo-controlled studies, 2,443 patients received placebo (n = 1,043), erenumab 70 mg (n

SUBMITTER: Kudrow D 

PROVIDER: S-EPMC7080286 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature