Microparticle-mediated VZV propagation and endothelial activation: Mechanism of VZV vasculopathy.

ABSTRACT: OBJECTIVE:Varicella zoster virus (VZV) can spread anterogradely and infect cerebral arteries causing VZV vasculopathy and arterial ischemic stroke. In this study, we tested the hypothesis that virus-infected cerebrovascular fibroblasts undergo phenotypic changes that promote vascular remodeling and facilitate virus transmission in an in vitro model of VZV vasculopathy. The aims of this project were therefore to examine the changes that virus-infected human brain adventitial vascular fibroblasts (HBVAFs) undergo in an in vitro model of VZV vasculopathy and to identify disease biomarkers relating to VZV-related vasculopathy. METHODS:HBVAFs were infected with VZV, and their ability to migrate, proliferate, transdifferentiate, and interact with endothelial cells was studied with flow cytometry

SUBMITTER: Eleftheriou D 

PROVIDER: S-EPMC7080289 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature