Elevation of CXCL1 indicates poor prognosis and radioresistance by inducing mesenchymal transition in glioblastoma.

ABSTRACT:

Introduction

Glioblastoma (GBM) is identified as a lethal malignant tumor derived from the nervous system. Despite the standard clinical strategy including maximum surgical resection, temozolomide (TMZ) chemotherapy, and radiotherapy, the median survival of GBM patients remains <15 months. Accumulating evidence indicates that rapid-acquired radioresistance is one of the most common reasons for GBM recurrence. Therefore, developing novel therapeutic targets for radioresistant GBM could yield long-term cures.

Aims

To investigate the functional role of CXCL1 in the acquired radioresistance and identify the molecular pathway correlated to CXCL1.

Results

In this study, we identified that CXCL1 is highly expressed in GBM and the elevation of CXCL1 is involved in radioresist

SUBMITTER: Alafate W 

PROVIDER: S-EPMC7080429 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature