Platelets trigger perivascular mast cell degranulation to cause inflammatory responses and tissue injury.

ABSTRACT: Platelet responses have been associated with end-organ injury and mortality following complex insults such as cardiac surgery, but how platelets contribute to these pathologies remains unclear. Our studies originated from the observation of microvascular platelet retention in a rat cardiac surgery model. Ensuing work supported the proximity of platelet aggregates with perivascular mast cells (MCs) and demonstrated that platelet activation triggered systemic MC activation. We then identified platelet activating factor (PAF) as the platelet-derived mediator stimulating MCs and, using chimeric animals with platelets defective in PAF generation or MCs lacking PAF receptor, defined the role of this platelet-MC interaction for vascular leakage, shock, and tissue inflammation. In application of t

SUBMITTER: Karhausen J 

PROVIDER: S-EPMC7080499 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature