GQSPSim: A SimBiology-Based GUI for Standardized QSP Model Development and Application.

ABSTRACT: Quantitative systems pharmacology (QSP) models are often implemented using a wide variety of technical workflows and methodologies. To facilitate reproducibility, transparency, portability, and reuse for QSP models, we have developed gQSPSim, a graphical user interface-based MATLAB application that performs key steps in QSP model development and analyses. The capabilities of gQSPSim include (i) model calibration using global and local optimization methods, (ii) development of virtual subjects to explore variability and uncertainty in the represented biology, and (iii) simulations of virtual populations for different interventions. gQSPSim works with SimBiology-built models using components such as species, doses, variants, and rules. All functionalities are equipped with an interactive vis

SUBMITTER: Hosseini I 

PROVIDER: S-EPMC7080534 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature