Engineering of Nebulized Metal-Phenolic Capsules for Controlled Pulmonary Deposition.

ABSTRACT: Particle-based pulmonary delivery has great potential for delivering inhalable therapeutics for local or systemic applications. The design of particles with enhanced aerodynamic properties can improve lung distribution and deposition, and hence the efficacy of encapsulated inhaled drugs. This study describes the nanoengineering and nebulization of metal-phenolic capsules as pulmonary carriers of small molecule drugs and macromolecular drugs in lung cell lines, a human lung model, and mice. Tuning the aerodynamic diameter by increasing the capsule shell thickness (from ≈100 to 200 nm in increments of ≈50 nm) through repeated film deposition on a sacrificial template allows precise control of capsule deposition in a human lung model, corresponding to a shift from the alveolar region to the b

SUBMITTER: Ju Y 

PROVIDER: S-EPMC7080547 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature