Radiation dose response of neurologic symptoms during conformal radiotherapy for diffuse intrinsic pontine glioma.

ABSTRACT:

Purpose

To estimate the rate and magnitude of neurologic symptom change during radiation therapy (RT) and impact of symptom change on survival outcomes in patients with diffuse intrinsic pontine glioma (DIPG).

Methods

From 2006 to 2014, 108 patients with newly diagnosed DIPG were treated with conventionally fractionated radiation therapy (RT) to 54 Gy (median) at our institution. The presence and severity of neurologic symptoms related to cranial neuropathy (CN) and cerebellar (CB) and long-tract (LT) signs was reviewed before and weekly during RT for each patient. The rate and magnitude of change for each symptom category was evaluated according to accumulated RT dose. The impact of clinical factors and radiation dose-volume parameters was determined using Cox proportional

SUBMITTER: Tinkle CL 

PROVIDER: S-EPMC7080561 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature