Adjunctive effect of the serotonin 5-HT_2C receptor agonist lorcaserin on opioid-induced antinociception in mice.

ABSTRACT: Opioid-sparing adjuncts are treatments that aim to reduce the overall dose of opioids needed to achieve analgesia, hence decreasing the burden of side effects through alternative mechanisms of action. Lorcaserin is a serotonin 5-HT_2C receptor (5-HT_2CR) agonist that has recently been reported to reduce abuse-related effects of the opioid analgesic oxycodone. The goal of our studies was to evaluate the effects of adjunctive lorcaserin on opioid-induced analgesic-like behavior using the tail-flick reflex (TFR) test as a mouse model of acute thermal nociception. We show that whereas subcutaneous (s.c.) administration of lorcaserin alone was inactive on the TFR test, adjunctive lorcaserin (s.c.) significantly increased the potency of oxycodone as an antinociceptive drug. T

SUBMITTER: Sierra S 

PROVIDER: S-EPMC7080563 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature