Association of neuronal repair biomarkers with delirium among survivors of critical illness.

ABSTRACT:

Purpose

Delirium is prevalent but with unclear pathogenesis. Neuronal injury repair pathways may be protective. We hypothesized that higher concentrations of neuronal repair biomarkers would be associated with decreased delirium in critically ill patients.

Materials and methods

We performed a nested study of hospital survivors within a prospective cohort that enrolled patients within 72 h of respiratory failure or shock. We measured plasma concentrations of ubiquitin carboxyl-terminal-esterase-L1 (UCHL1) and brain-derived neurotrophic factor (BDNF) from blood collected at enrollment. Delirium was assessed twice daily using the CAM-ICU. Multivariable regression was used to examine the associations between biomarkers and delirium prevalence/duration, adjusting for covariates a

SUBMITTER: Hayhurst CJ 

PROVIDER: S-EPMC7080575 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature