Dose escalation of an Evans blue-modified radiolabeled somatostatin analog ¹⁷⁷Lu-DOTA-EB-TATE in the treatment of metastatic neuroendocrine tumors.

ABSTRACT:

Purpose

To evaluate the safety and efficacy of ¹⁷⁷Lu-DOTA-EB-TATE, a radiolabeled somatostatin analog modified by Evans blue, at escalating doses, was used to increase tumor retention in patients with progressive metastatic neuroendocrine tumors (NETs).

Methods

Thirty-three patients with metastatic NETs were prospectively enrolled into four groups: group A (n = 6, 43 ± 12 years) administered approximately 3.7 GBq (100 mCi) ¹⁷⁷Lu-DOTATATE as controls; group B (n = 7, 55 ± 7 years) administered approximately 1.11 GBq (30 mCi) ¹⁷⁷Lu-DOTA-EB-TATE; group C (n = 6, 55 ± 10 years) administered approximately 1.85 GBq (50 mCi) ¹⁷⁷Lu-DOTA-EB-TATE; group D (n = 14, 50 ± 10 years) administered approximately 3.7 GBq (100 mCi) ¹⁷⁷Lu-D

SUBMITTER: Liu Q 

PROVIDER: S-EPMC7080608 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature