Screening ginseng saponins in progenitor cells identifies 20(R)-ginsenoside Rh₂ as an enhancer of skeletal and cardiac muscle regeneration.

ABSTRACT: Aging is associated with increased prevalence of skeletal and cardiac muscle disorders, such as sarcopenia and cardiac infarction. In this study, we constructed a compendium of purified ginsenoside compounds from Panax ginseng C.A. Meyer, which is a traditional Korean medicinal plant used to treat for muscle weakness. Skeletal muscle progenitor cell-based screening identified three compounds that enhance cell viability, of which 20(R)-ginsenoside Rh₂ showed the most robust response. 20(R)-ginsenoside Rh₂ increased viability in myoblasts and cardiomyocytes, but not fibroblasts or disease-related cells. The cellular mechanism was identified as downregulation of cyclin-dependent kinase inhibitor 1B (p27^Kip1) via upregulation of Akt1/PKB phosphorylation at seri

SUBMITTER: Kim AR 

PROVIDER: S-EPMC7080739 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature