MicroRNA-875-5p plays critical role for mesenchymal condensation in epithelial-mesenchymal interaction during tooth development.

ABSTRACT: Epithelial-mesenchymal interaction has critical roles for organ development including teeth, during which epithelial thickening and mesenchymal condensation are initiated by precise regulation of the signaling pathway. In teeth, neural crest-derived mesenchymal cells expressed PDGF receptors migrate and become condensed toward invaginated epithelium. To identify the molecular mechanism of this interaction, we explored the specific transcriptional start sites (TSSs) of tooth organs using cap analysis of gene expression (CAGE). We identified a tooth specific TSS detected in the chromosome 15qD1 region, which codes microRNA-875 (mir875). MiR875-5p is specifically expressed in dental mesenchyme during the early stage of tooth development. Furthermore, PRRX1/2 binds to the mir875 promoter regio

SUBMITTER: Funada K 

PROVIDER: S-EPMC7080778 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature