PIANO: A Web Server for Pseudouridine-Site (Ψ) Identification and Functional Annotation.

ABSTRACT: Known as the "fifth RNA nucleotide", pseudouridine (Ψ or psi) is the first-discovered and most abundant RNA modification occurring at the Uridine site, and it plays a prominent role in a number of biological processes. Thousands of Ψ sites have been identified within different biological contexts thanks to the advancement in high-throughput sequencing technology; nevertheless, the transcriptome-wide distribution, biomolecular functions, regulatory mechanisms, and disease relevance of pseudouridylation are largely elusive. We report here a web server-PIANO-for pseudouridine site (Ψ) identification and functional annotation. PIANO was built upon a high-accuracy predictor that takes advantage of both conventional sequence features and 42 additional genomic f

SUBMITTER: Song B 

PROVIDER: S-EPMC7080813 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature