Epigenome-wide association study for perceived discrimination among sub-Saharan African migrants in Europe - the RODAM study.

ABSTRACT: Sub-Saharan African (SSA) migrants in Europe experience psychosocial stressors, such as perceived discrimination (PD). The effect of such a stressor on health could potentially be mediated via epigenetics. In this study we performed an epigenome-wide association study (EWAS) to assess the association between levels of PD with genome-wide DNA methylation profiles in SSA migrants. The Illumina 450 K DNA-methylation array was used on whole blood samples of 340 Ghanaian adults residing in three European cities from the cross-sectional Research on Obesity and Diabetes among African Migrants (RODAM) study. PD was assessed using sum scores of the Everyday Discrimination Scale (EDS). Differentially methylated positions and regions (DMPs and DMRs) were identified through linear regression analysis.

SUBMITTER: van der Laan LC 

PROVIDER: S-EPMC7080832 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature