Risk of Overdose with Exposure to Prescription Opioids, Benzodiazepines, and Non-benzodiazepine Sedative-Hypnotics in Adults: a Retrospective Cohort Study.

ABSTRACT:

Background

Concurrent use of benzodiazepines in opioid users has been linked to a higher risk of an emergency room visit or inpatient admission for opioid overdose and death from drug overdose. Further research is needed to confirm the findings and analyze contributing risk factors for opioid overdoses in a large commercially insured population.

Objectives

To estimate the risk of opioid overdose associated with opioid users exposed to various combinations of opioid, benzodiazepine, and non-benzodiazepine sedative-hypnotic therapy. To identify other factors that are associated with increased risk for opioid overdose.

Design

Retrospective cohort study.

Patients

New start adult users of opioids, defined as naïve to opioids for 6 months, in Kaiser Permanente Califo

SUBMITTER: Cho J 

PROVIDER: S-EPMC7080944 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature