Identification and Validation of Immune-Related Gene Prognostic Signature for Hepatocellular Carcinoma.

ABSTRACT: Immune-related genes (IRGs) have been identified as critical drivers of the initiation and progression of hepatocellular carcinoma (HCC). This study is aimed at constructing an IRG signature for HCC and validating its prognostic value in clinical application. The prognostic signature was developed by integrating multiple IRG expression data sets from TCGA and GEO databases. The IRGs were then combined with clinical features to validate the robustness of the prognostic signature through bioinformatics tools. A total of 1039 IRGs were identified in the 657 HCC samples. Subsequently, the IRGs were subjected to univariate Cox regression and LASSO Cox regression analyses in the training set to construct an IRG signature comprising nine immune-related gene pairs (IRGPs). Functional analyses reve

SUBMITTER: Chen W 

PROVIDER: S-EPMC7081044 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature