Changes in extracellular matrix in different stages of colorectal cancer and their effects on proliferation of cancer cells.

ABSTRACT:

Background

The extracellular matrix is the main component of the tumor microenvironment. Extracellular matrix remodels with the oncogenesis and development of tumors. Previous studies usually focused on the changes of proteins in normal colorectal tissues and colorectal cancers. Little is known about the changes in the extracellular matrix in different stages of colorectal cancer and the effects of these changes on the development of this cancer.

Aim

To test the changes of type I collagen, type IV collagen, matrix metalloproteinase-2 (MMP-2), matrix metalloproteinase-9 (MMP-9), and tissue inhibitor of metalloproteinase-3 (TIMP-3) in different stages of colorectal cancer and the effects of these changes on the proliferation of cancer cells.

Methods

The extracellular ma

SUBMITTER: Li ZL 

PROVIDER: S-EPMC7081112 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature