Calcium Intake and Risk of Colorectal Cancer According to Tumor-infiltrating T Cells.

ABSTRACT: Calcium intake has been associated with a lower risk of colorectal cancer. Calcium signaling may enhance T-cell proliferation and differentiation, and contribute to T-cell-mediated antitumor immunity. In this prospective cohort study, we investigated the association between calcium intake and colorectal cancer risk according to tumor immunity status to provide additional insights into the role of calcium in colorectal carcinogenesis. The densities of tumor-infiltrating T-cell subsets [CD3⁺, CD8⁺ , CD45RO (PTPRC) ⁺ , or FOXP3⁺ cell] were assessed using IHC and computer-assisted image analysis in 736 cancer cases that developed among 136,249 individuals in two cohorts. HRs and 95% confidence intervals (CI) were calculate

SUBMITTER: Yang W 

PROVIDER: S-EPMC7081141 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature